ea0019p21 | Bone | SFEBES2009
Dobson Pauline
, Collins John
, El-Mastry Omar
, Goldring Mary
, Brown Barry
AMP-activated protein kinase (AMPK) acts as a sensor and regulator of cellular energy homeostasis. Once activated, AMPK influences a number of responses including inhibition of anabolic pathways and the switching-on of catabolic pathways. Regulation of AMPK, which responds to an increase in the AMP/ATP ratio, could have an important role in chondrocyte function particularly in response to hormones and to stress such as occurs in osteoarthritis. Therefore, we sought to investig...